Correlation study of gene polymorphism of CYP2C19 and anticoagulation effect of clopidogrel
CAI Hong-min
CHEN Hui
ZHAO Guan-ren
LI Su
FENG Duan-hao
Abstract：Objective:To explore the correlation between the gene polymorphism of CYP2C19 and anticoagulation effect of clopidogrel, and provide the reference for individualized medication of clopidogrel. Methods:The peripheral bloods of 176 post-PCI patients who were diagnosed with acute coronary syndromes were drawn, genomic DNAs were extracted and amplified by PCR, and then the genotypes of those samples were identified by gene chips hybridization. The subjects were divided into three groups by genotype. Group A consisted of patients with the genotype of extensive metabolism (CYP2C19*1/*1), group B consisted of patients with the genotype of intermediated metabolism (CYP2C19*1/*2 and CYP2C19*1/*3), and group C consisted of patients with the genotype of poor metabolism (CYP2C19*2/*2, CYP2C19*2/*3 and CYP2C19*3/*3). The ADP inhibition rates in different groups were evaluated. The data were analyzed by SPSS 13.0 software. Results:There were no significant differences of ADP inhibition rate among the three groups (P >0.05), but when compared to group B and group A, the ADP inhibition rates in group C were significantly lower in 127 patients with first PCI (P<0.05 and P<0.01). Conclusion:The anticoagulant effect of clopidogrel in the CYP2C19 poor metabolism genotype patients with first PCI was poor.
Keywords：CYP2C19Gene polymorphismClopidogrelADP inhibition rate
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 254-257 )