Efficacy observation of low-dose EP regimen in the treatment of small cell lung cancer patients with hepatic metastasis and severe liver dysfunction
MU Tie-jun
LI Guang-qing
HE Yan-hu
Abstract：Objective: To observe the improvement of liver function by using low-dose EP regimen (etoposide and cisplatin) in small cell lung cancer patients with hepatic metastasis and severe liver dysfunction. Methods:From 2007 to 2012, chemotherapy-naive patients who had small cell lung cancer with severe liver dysfunction (aspartate aminotransferase and/or alanine aminotransferase≥5×ULN, total bilirubin≥3×ULN before chemotherapy) secondary to hepatic metastasis were recruited, and treated with low-dose EP regimen which was intravenous infusion of etoposide 100 mg and cisplatin 20 mg from day 1 to 5 with every 3 weeks as a cycle. Liver function indexes were tested after two cycles of chemotherapy. Results:All those patients' liver function improved after chemotherapy. Conclusion:After the exclusion of other liver diseases, low-dose EP regimen was relatively safe in the small cell lung cancer patients with hepatic metastasis and severe liver dysfunction, and could improve the patients' liver function. The further study should be warranted to conifrm the clinical effect.
Keywords：Small cell lung cancerEtoposideCisplatinHepatic metastasisLiver dysfunction
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 252-253,254 )