Salivation increased due to spironolactone
HUO Xia
Abstract：One 84-year-old man with cough, expectoration, wheeze especially after activity, was diagnosed as chronic bronchitis. The condition of the patient was improved after the use of antimicrobial drugs. The reduced exercise tolerance occurred due to reduced heart function associated with pulmonary infection. Then the spironolactone with a dose of 20 mg once a day was administered to improve cardiac function. Three days later, there was obviously increased salivation resulted in aspiration. The spironolactone was subsequently stopped and antibiotic therapy was continued. The patient's salivation gradually reduced and the general condition became better. After 3 months, the patient suffered the fever and cough with yellowish sputum, heart rate increased, feeble, palpitation, dyspnea again. Meropenem for injection was used, and the digoxin 0.125 g once a day, spironolactone 20 mg once a day were added to sustain the cardiac function. The salivation occurred again after 3 days use of spironolactone. The symptom of salivation disappeared after spironolactone withdrawal for 2 days.
Keywords：SpironolactoneSalivation increasedAdverse drug reaction
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 242-242,243 )