Study on pharmacokinetics of icariin loaded solid lipid nanoparticles in rats
LIU Cong-cong
ZHANG Qi
SUN Xue-hui
GUO Tao
Abstract：Objective:To investigate the pharmacokinetics of icariin (ICA) loaded solid lipid nanoparticles (ICA-SLN) in rats and to evaluate the feasibility of improving ICA's oral bioavailability. Methods: Using HPLC-MS/MS to determine the concentration of ICA in rats after oral administration of ICA suspension and ICA-SLN respectively, the pharmacokinetic parameters of two goups were calculated by DAS 2.0 software. Results:There were two peaks in drug concentration-time profile of ICA, tmax was 1 h, t1/2 was 3 h. AUC0-∞of oral ICA-SLN groups and ICA groups were (233.6 ± 71.2) ng· h· mL-1, (107.4 ± 15.7)ng· h· mL-1 respectively (P<0.05). Conclusion:Compared with ICA, ICA-SLN is a promising delivery system to enhance the bioavailability of ICA in rats.
Keywords：Icariin (ICA)Solid lipid nanoparticlesPharmacokineticsBioavailability
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 203-205,206 )