Experimental study on skin irritation and anaphylaxis of nano-fibers tunic carbonized hair loaded drug
ZHANG Jie-bing
LIU Mei
SI Liang-hong
LU Yi
MA Jing
QIU Yan
Abstract：Objective:To evaluate the safety of the nano-fibers tunic carbonized hair loaded drug (NTCH) by skin irritation and anaphylaxis experiment. Methods: Skin irritation test was carried out on the integral skin and the damaged skin of rabbits, which was observed at 1 day and 7 days with the NTCH. Skin allergy test was carried out on the slain of the guinea pigs with NTCH once a week for 3 consecutive weeks, and the animals were stimulated at the 28th day. Then irritation and allergic reactions of the animals were investigated. Results:There was no erythema and edema at 1 h, 24 h, 48 h and 72 h after single dose or multiple doses of NTCH. The average reaction values of the NTCH on integral and damaged skin were lower than 0.5, and there was no irritation of NTCH on integral and damaged skin of rabbits. There was no allergic reactions such as erythema and edema or systemic allergic reactions in guinea pigs skin test. Conclusion:The NTCH is a safe external drug without irritation on integral and damaged skin of rabbit and anaphylaxis effect on the skin of guinea pig.
Keywords：Carbonized hairNano-fibers tunicIrritationAnaphylaxis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 197-199 )