Drug-induced factors analysis of grand mal epilepsy in patient with pure red cell aplastic anemia
JIANG Hao
CHEN Ying
HE Ju-ying
Abstract：One 77-year-old female patient, who was diagnosed with pure red cell aplastic anemia, was given levofloxacin (0.2 g, ivgtt, bid) and cyclosporine A (100 mg, po, q 12 h) successively. One day later, the patient developed transient tic, non-response to calling, urinary incontinence. Ten minutes later, the symptom slightly relieved. But 30 minutes later, the patient had symptoms with rigidity of limbs tic, unconsciousness, staring eyes on the left, foaming at the mouth and non-response to calling. Then she received diazepam (10 mg, iv), while she still had intermittent tremor in lower limbs. Then the cyclosporine was stopped and valproate sodium for injection (0.4 g, ivgtt, bid) was given for symptomatic treatment, after the condition was stable, valproate sodium for injection was replaced to sodium valproate sustained-release tablets (0.5 g, bid). The patient was still unconsciousness. The adverse drug reaction (ADR) may be caused by evaluated concentration of cyclosporin A when combination use of levofloxacin, while the possibility of levofloxacin-induced ADR was little.
Keywords：Cyclosporin ALevofloxacinGrand mal epilepsyDrug interaction
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 181-182 )