Two cases of drug-induced hepatitis caused by Polygonum multiflorum
Abstract：Case one, one 52-year-old female patient took the mixture of Polygonum multiflori radix praeparata, walnut and sesame (including Polygonum multiflori radix praeparata 250 g, walnut 200 g and sesame 150 g, 15 g once a day) for immune enhancement. About twenty days later,the patient developed yellow skin and scleral icterus, lack of power, nausea and anorexia. Results of liver function examination were as follows:TBIL 116 μmol·L-1, ALT 1105 U·L-1, AST 1110 U·L-1. The patient was hospitalized and the labortory test results met the diagnosis criteria for drug-induced hepatitis.After 24-day treatment with tiopronin, compound glycyrrhizin, silymarin and anethol trithione for liver impairment, her hepatic function returned to normal. Case two, one 61-year-old female patient took the mixture of hawthorn, lotus leaf and Polygonum multiflori radix for the treatment of hyperlipemia. After about six months, the patient developed fever, malaise, anorexia and abdominal distention. Results of liver function examination were as follows:TBIL123.0 μmol·L-1, DBIL 105.0 μmol·L-1, AKP 284.0 U·L-1, γ-GT 330 U·L-1. The patient was hospitalized and the labortory test results met the diagnosis criteria for drug-induced hepatitis. After 40-day treatment with tiopronin, compound glycyrrhizin and tanreqing injection for liver impairment, her hepatic function returned to normal.
Keywords：Polygonum multiflorumDrug-induced hepatitisLiver impairmentAdverse drug reaction
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)