Causal association between adult-onset Still's disease and coronary heart disease coronary atherosclerotic heart disease:a Mendelian randomization study
YIN Jiajie
LIANG Shichao
GAO Yijie
WANG Baofu
LUO Fangyuan
LI Xianlun
Abstract：Objective To analyze the causal association between adult-onset Still's disease(AOSD)and coronary atherosclerotic heart disease(CHD)by using the Mendelian randomization(MR)method.Methods Two-sample MR analysis was performed via the genome-wide association study(GWAS)summary database,adopting the inverse variance weighting(IVW)method,weighted median method and MR-Egger regression method.The credibility of the results was further evaluated by the multivariable Mendelian randomization(MVMR)method.Results A causal association was identified between AOSD and CHD increased risk(IVW:OR=1.039,95%CI:1.014～1.064,P=0.001).In the MR analysis,no horizontal pleiotropy or heterogeneity was found in the instrumental variables.Sensitivity analysis using leave-one-out method(LOO)confirmed the robustness of the MR results.Additionally,after adjusting for confounding factors by MVMR method,the above causal association remained statistically significant(OR=1.104,95%CI:1.022～1.192,P=0.012).Conclusion The results of MR analysis indicate that AOSD has a causal association with CHD elevated risk.
Keywords：coronary heart diseaseadult-onset Still's diseaseMendelian randomization
Publication Date：2026-02-20
Online Publishing Date：2026-03-19(First online date of this platform, not the publication date of the document)
Pages：5( 135-139 )