Correlation among protease-activated receptor-2,secreted frizzled-related protein-5 and postoperative in-stent restenosis in patients with coronary heart disease
WANG Yanli
ZANG Guanda
LUO Jinguang
ZHANG Xiaobo
Abstract：Objective To investigate the correlation between levels of serum protease-activated receptor-2(PAR-2)and secreted frizzled-related protein-5(SFRP-5)and postoperative in-stent restenosis(ISR)in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods CHD patients(n=200)underwent PCI were selected in Anyang People's Hospital from July 2022 to Aug.2024.According to results of coronary angiography(CAG)after PCI for 6 month,the patients were divided into ISR group(n=50)and non-ISR group(n=150).The levels of serum PAR-2 and SFRP-5 were compared between 2 groups,and were compared among CHD patients with different degrees of coronary artery stenosis.The correlation among PAR-2,SFRP-5 and coronary artery stenosis after PCI was analysis using Pearson analysis.Results The level of PAR-2 was higher,and level of SFRP-5 was lower in ISR group than that in non-ISR group(P<0.050).The level of PAR-2 was higher,and level of SFRP-5 was lower in severe CHD group than that in mild CHD group(P<0.050).The results of Pearson analysis showed that PAR-2 was positively correlated to coronary artery stenosis,and SFRP-5 was negatively correlated to coronary artery stenosis after PCI(P<0.050).Conclusion The elevation of postoperative ISR is closely correlated to increased PAR-2 level and decreased SFRP-5 level in CHD patients after PCI,and dynamic monitoring of which is helpful to prevent the occurrence of ISR.
Keywords：coronary heart diseasepercutaneous coronary interventionin-stent restenosisprotease-activated receptor-2secreted frizzled-related protein-5
Publication Date：2026-01-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：4( 43-46 )