Influence of left bundle branch area pacing on cardiac chamber and cardiac function in patients undergoing cardiac pacemaker implantation
LI Zuoling
PEI Xiaoling
LIN Yan
LONG Jiao
YANG Yang
Abstract：Objective To explore the influence of left bundle branch area pacing(LBBAP)on cardiac chamber and cardiac function in patients undergoing cardiac pacemaker implantation.Methods The data of patients underwent cardiac pacemaker implantation was retrospectively analyzed in Chengdu Third People's Hospital from Jan.2022 to June 2024.According to the different implantation sites of cardiac pacing electrodes,the patients were divided into right ventricular apical pacing(RVAP)group(underwent traditional RVAP)and LBBAP group(underwent LBBAP).Propensity score matching was adopted(with a caliper value of 0.01 and a matching ratio of 1:1),and 83 cases were enrolled in each group.The changes in pacing parameters(sensing,impedance,threshold)immediately after surgery,at 7 d,6 months,and 1 y postoperatively,as well as the changes in ventricular atrioventricular synchrony indicators[the ratio of left ventricular filling time to cardiac cycle(LVFT/RR),electrocardiogram QRS complex duration]immediately after surgery,at 1 month,6 months,and 1 y postoperatively were compared between 2 groups.The changes in ECG parameters[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left atrial diameter(LAD)]and cardiac function classification were compared between 2 groups before surgery and 6 months and 1 y after surgery,and the incidence of complications was statistically analyzed in both groups.Results There were no statistically significant differences in pacing sensing between groups,at different time points,and at interaction level(P>0.05).For pacing threshold and impedance,no statistically significant differences were observed at the interaction and inter-group levels(P>0.05),while the differences at the time level were statistically significant(P<0.050).There were statistically significant differences in LVFT/RR and QRS complex duration between groups,at different time points,and at interaction level(P<0.050).LVFT/RR,QRS complex duration and Ts-LV-RV were lower in LBBAP group than those in RVAP group at 1 month,6 months and 1 y after surgery(P<0.050).There were statistically significant differences in Ts-LV-RV between groups and at different time points(P<0.050).At 1 y after surgery,LVEDD was lower than that immediately after surgery(P<0.050).At 6 months and 1 y after surgery,NYHA classification was superior to that before surgery(P<0.050),and was superior in LBBAP group to that in RVAP group(P<0.050).There were no incision bleeding,pocket hematoma,infection,electrode displacement,or death occurred in either group after surgery.Conclusion The application of LBBAP can effectively improve the mechanical synchronicity,and then enhance heart function in patients with cardiac pacemaker implantation.
Keywords：left bundle branch area pacingcardiac pacemaker implantationright ventricular pacingheart function
Publication Date：2026-01-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：6( 37-42 )