Professor Sun Tianfu's medication law and effective mechanism in treating coronary heart disease-angina pectoris:a study bases on data mining and network pharmacology
DONG Xusheng
SUN Tianfu
GUO Mingzhen
YAO Zhuangxian
LI Chaofan
XU Qian
Abstract：Objective To discuss Professor Sun Tianfu's medication law and effective mechanism of in treating coronary heart disease-angina pectoris(CHD-AP)bases on data mining and network pharmacology.Methods Professor Sun Tianfu's effective medical records were collected to establish a medical record database from Jan.2021 to Oct.2023.The data of formulas in medical records were given frequency,association rule and cluster analyses by using Ancient and Modern Medical Record Cloud Platform(V2.3.7),Excel and SPSS software for digging common medicinal pairs and medicinal combinations and obtaining a core compound formula.The chemical composition and action targets were screened from the core compound formula by using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).The disease targets related to CHD-AP were screened from databases of DrugBank,GeneCards,TTD and OMIM.The medicinal-disease intersection targets were introduced into STRING platform to establish a protein target interaction network diagram(PPI),and the intersection targets were introduced into Metascape database for GO and KEGG analyses.Results There were 214 formulas screened out for treating CHD-AP involved 175 Chinese medicinals,mainly tonifying,tranquilizing and qi-regulating medicinals.he components of the core compound formula included Taizishen(Radix Pseudostellariae),Suanzaoren(Semen Ziziphi Spinosae),Maidong(Radix Ophiopogonis),Guizhi(Ramulus Cinnamomi),Wuweizi(Fructus Schisandrae),Xianhecao(Herba Agrimoniae)and Tanxiang(Lignum Santali).A total of 45 active components,443 gene targets,1486 disease targets and 178 medicinal-disease intersection targets were screened out.A total of 2200 biological processes,113 cellular components,196 molecular functions and 212 biological pathways were obtained by GO and KEGG enrichment analysis.Conclusion Professor Sun Tianfu's therapy for CHD-AP is mainly based on tonifying and heart-nourishing,as well as protecting spleen-lung qi and eliminating the pathogen.The core Chinese medicinals play a role in treating CHD-AP possibly through anti-inflammatory,anti-oxidative stress,inhibiting platelet aggregation and regulating lipid metabolism.
Keywords：coronary heart disease-angina pectorismedication laweffective mechanismnetwork pharmacology
Publication Date：2026-01-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：8( 8-15 )