Etiological characteristics,risk factors and prevention and control strategies of multidrug-resistant organism infections after surgery for Stanford type A aortic dissection
ZHI Qing
ZHONG Xufang
SUN Yao
DU Xia
Abstract：Objective To study the etiological characteristics,risk factors and prevention and control strategies of infections of multidrug-resistant organism(MDRO)after surgery for Stanford type A aortic dissection(TAAD).Methods A retrospective analysis was conducted on 292 patients with TAAD who underwent surgical treatment in First Affiliated Hospital of Chinese PLA Air Force Medical University from Jan.2022 to Dec.2024,and their postoperative infection status was statistically analyzed.Patients with postoperative MDRO infection were assigned to MDRO group,while patients without MDRO infection were randomly selected from the remaining patients at a ratio of 1:4 to form non-MDRO group.Clinical data were collected in 2 groups,and Logistic regression model was used to analyze the risk factors.The receiver operating characteristic(ROC)curve was plotted based on the probability values fitted by the regression equation.Results There were 18 cases of postoperative MDRO infection(6.16%),with 32 strains of MDRO pathogens,among which gram-negative bacteria were the main pathogens.A total of 72 patients were randomly selected into non-MDRO group at a ratio of 1:4.The results of multi-factor Logistic regression analysis showed that age,operation time,length of stay in ICU and indwelling time of central venous catheter were independent risk factors for postoperative MDRO infection in TAAD patients(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of the combined prediction for postoperative MDRO infection was 0.968,with a 95%confidence interval(95%CI)of 0.925-1.000,a sensitivity of 0.944,and a specificity of 0.944.Conclusion The pathogens causing MDRO infection after TAAD surgery are mainly gram-negative bacteria.Age,operation time,length of stay in ICU and indwelling time of central venous catheter are independent risk factors for MDRO infection after TAAD surgery.Prevention and control measures should be implemented from three aspects:strengthening management,enhancing prevention and control measures,and rational use of antimicrobial agents,so as to reduce the risk of MDRO infection.
Keywords：stanford type a aortic dissectionmultidrug-resistant organismpostoperative infectionetiological characteristicsrisk factors
Publication Date：2025-12-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：5( 1487-1491 )