Relationship among electrocardiogram parameters,ventricular arrhythmias and heart function in patients with chronic heart failure
JIANG Guiyao
JIANG Yi
LIU Ronghua
CHEN Hang
LUO Man
JIANG Nan
LIN Guowei
Abstract：Objective To observe the changes of electrocardiogram(ECG)-related parameters and their association with ventricular arrhythmia(VA)and heart function in patients with chronic heart failure(CHF).Methods A total of 108 CHF patients admitted to Zigong First People's Hospital were enrolled from May 2020 to May 2024.The patients were divided into a VA group and a non-VA group based on the presence or absence of VA.By analyzing the changes in ECG-related parameters of CHF patients,the relationship among these parameters,risk of VA occurrence and heart function was discussed.Results There were significant differences in drinking history,heart failure classification,QTc interval,TP-Tec interval,and Tp-Te/QT ratio between VA group and non-VA group among(P<0.05).Logistic regression analysis showed that:model 1:QTc interval(OR=3.122,95%CI:1.439～6.773,P<0.05),TP-Tec interval(OR=5.881,95%CI:2.449～14.124,P<0.05),and Tp-Te/QT ratio(OR=4.161,95%CI:1.847～9.376,P<0.05)were all independent predictors of VA occurrence in CHF patients,model 2:heart failure with mid-range ejection fraction(HFmrEF,OR=5.747,95%CI:1.849～17.863,P<0.05),heart failure with reduced ejection fraction(HFrEF,OR=6.845,95%CI:1.817～25.791,P<0.05),and drinking history(OR=3.775,95%CI:1.112-12.807,P<0.05)were independent risk factors for VA occurrence in CHF patients,and model 3:QTc interval combined with drinking history(OR=1.002,95%CI:1.000～1.005,P<0.05)and TP-Tec interval combined with drinking history(OR=1.011,95%CI:1.001～1.021,P<0.05)revealed an interaction effect in VA occurrence among CHF patients.The results of ROC curve analysis demonstrated that AUC of QTc interval,TP-Tec interval,and Tp-Te/QT ratio for predicting VA in CHF patients were 0.774(95%CI:0.686～0.862,P<0.05),0.813(95%CI:0.730～0.897,P<0.05),and 0.803(95%CI:0.721～0.885,P<0.05),respectively.The results of Pearson correlation analysis indicated that QTc interval,TP-Tec interval,and Tp-Te/QT ratio were negatively correlated with left ventricular ejection fraction(LVEF)in CHF patients(r=-0.272,r=-0.262,r=-0.302,all P<0.05).There were significant differences in QTc interval,TP-Tec interval,and Tp-Te/QT ratio among 3 subgroups stratified by heart failure type(P<0.05),specifically,these indices were significantly higher in patients with HFmrEF and HFrEF than in those with heart failure with preserved ejection fraction(HFpEF,P<0.05).The results of linear regression analysis showed that Tp-Te/QT ratio was an independent risk factor for LVEF decline in CHF patients(t=-2.179,P<0.05).Conclusion The abnormal changes of QTc,TP-Tec and Tp-Te/QT are closely correlated to VA occurrence in CHF patients,which has some value to risk assessment.
Keywords：chronic heart failureventricular arrhythmiaselectrocardiogramheart function
Publication Date：2025-12-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：6( 1464-1469 )