Relationship among endothelial cell specific molecule-1,hypoxia inducible factor-1α and coronary collateral circulation formation in patients with unstable angina pectoris
CHEN Mantian
SUN Yinggang
TANG Yong
Abstract：Objective To investigate the relationship among endothelial cell specific molecule-1(ESM-1),hypoxia inducible factor-1α(HIF-1α)and coronary collateral circulation(CCC)formation in patients with unstable angina pectoris(UAP).Methods UAP patients(n=158)were selected into UAP group,patients with stable angina pectoris(SAP)were selected into SAP group(n=79)and patients with acute myocardial infarction(AMI)were selected into AMI group(n=79)in Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine from Jan.2022 to Sept.2024.The levels of ESM-1 and HIF-1α were detected and compared in 3 groups.According to CCC status in UAP patients,they were divided into poor CCC group(n=60)and good CCC group(n=98),and levels of ESM-1 and HIF-1α were compared between these 2 groups.The relationship among ESM-1,HIF-1α and poor CCC was analyzed.Results The levels of ESM-1 and HIF-1α were higher in AMI group and UAP group than those in SAP group,and were higher in AMI group than those in UAP group(P<0.05).The levels of ESM-1 and HIF-1α were higher in poor CCC group than those in good CCC group(P<0.05).The results of single-factor analysis showed that the proportion of complicated diabetes and smoking history were higher in poor CCC group than those in good CCC group(P<0.05).The results of multi-factor Logistic regression analysis showed that complicated diabetes,smoking history and higher levels of ESM-1 and HIF-1α were influence factors for poor CCC formation(P<0.05).Conclusion The levels of serum ESM-1 and HIF-1α are risk factors for poor CCC formation in UAP patients.
Keywords：unstable angina pectorisendothelial cell specific molecule-1hypoxia inducible factor-1αcoronary collateral circulationstable angina pectorismyocardial infarctioninfluence factors
Publication Date：2025-12-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：5( 1422-1426 )