Correlation between mean arterial pressure and in-hospital mortality in patients with acute myocardial infarction
WEN Tong
ZHOU Jing
QIU Xincheng
JIN Zhitao
ZHANG Zheng
HU Lihua
HU Taohong
Abstract：Objective To investigate the relationship between level of mean arterial pressure(MAP)on admission and in-hospital mortality in patients with acute myocardial infarction(AMI).Methods AMI patients(n=869)were selected from Characteristic Medical Center of Chinese PLA Rocket Force from Mar.2015 to Jan.2020.The relationship between MAP admission and in-hospital mortality was statistically analyzed by using Logistic regression model,and HR and 95%CI were calculated.The relationship between MAP admission and in-hospital mortality was discussed by using restricted cubic spline(RCS)plots and inflection analysis.Results A total of 869 patients with AMI were included in this study.After adjusting for clinical features related to in-hospital all-cause mortality,MAP was an independent predictor of mortality in AMI patients.Compared with those with MAP<87.6 mmHg(1 mmHg=0.133 kPa),the patients with MAP≥98.2 mmHg had a significantly lower risk of in-hospital death,(HR=0.18,P<0.05).The results of RCS plots and inflection analyses showed an L-shaped curve of in-hospital all-cause mortality between MAP and AMI(P<0.05).In the inflection point analysis,patients with MAP<91 mmHg had a decreased risk of in-hospital mortality with increasing MAP(P<0.05).When MAP≥91 mmHg,there was no significant correlation between MAP and in-hospital mortality(P>0.05).Conclusion MAP may be an independent risk factor for in-hospital all-cause mortality,and an L-shaped relationship was found between MAP and in-hospital all-cause mortality in AMI patients.
Keywords：acute myocardial infarctionmean arterial pressureIn-hospital mortalityprognosis
Publication Date：2025-11-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：6( 1383-1388 )