Relationship between HRV,baPWV and inflammatory factors and the circadian rhythm of blood pressure in patients with essential hypertension
ZHENG Huasong
SUN Xudu
SHI Suna
YANG Liu
LIU Jie
DONG Mei
Abstract：Objective To analyze the relationship of heart rate variability(HRV),brachial-ankle pulse wave velocity(baPWV)and inflammatory factors with blood pressure circadian rhythm in patients with essential hypertension.Methods A retrospective analysis was conducted on the clinical data of 118 patients with essential hypertension admitted to our hospital from January 2022 to January 2024.According to the nighttime blood pressure decline rate,43 patients with non-dipper hypertension were assigned to group A and 75 patients with dipper hypertension to group B.Blood pressure circadian rhythm,HRV parameters,baPWV,and inflammatory factor levels were compared between the two groups.The relationships between nighttime blood pressure decline rate and HRV parameters,baPWV,IL-6,and TNF-α levels were also analyzed.Results Compared with group B,group A had higher 24-hour mean systolic blood pressure(24h SBP),24-hour mean diastolic blood pressure(24h DBP),daytime mean systolic blood pressure(dSBP),daytime mean diastolic blood pressure(dDBP),nighttime mean systolic blood pressure(nSBP),nighttime mean diastolic blood pressure(nDBP)],baPWV,interleukin-6 and tumor necrosis factor(TNF)-α(P<0.05),while the standard deviation of normal RR intervals(SDNN),low frequency power(LF)and LF/HF were lower(P<0.05).There were no significant differences between the two groups in standard deviation of 5-minute mean RR intervals(SDANN),root mean square of difference(rMSSD),percentage of difference>50ms(PNN50)and high frequency power(HF)(P>0.05).Pearson correlation analysis showed that nighttime blood pressure decline rate was negatively correlated with baPWV,IL-6,and TNF-α(P<0.05),and positively correlated with SDNN,LF,and LF/HF(P<0.05).Conclusion The circadian rhythm of blood pressure in patients with essential hypertension is significantly correlated with HRV,baPWV,and inflammatory factors,which are associated with cardiovascular events.
Keywords：essential hypertensionheart rate variabilityblood pressure circadian rhythminflammatory factorsbrachial-ankle pulse wave velocity
Publication Date：2025-11-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：4( 1349-1352 )