Correlation among neutrophil gelatinase-associated lipocalin,adiponectin,soluble suppression of tumorigenicity 2,C-type natriuretic peptide and left ventricular hypertrophy in patients with essential hypertension
MA Hong'en
WANG Xin
JI Zhaohong
WEI Wenyang
ZHOU Na
Abstract：Objective To explore the correlation among neutrophil gelatinase-associated lipocalin(NGAL),adiponectin(APN),soluble suppression of tumorigenicity 2(sST2),C-type natriuretic peptide(CNP)and left ventricular hypertrophy(LVH)in patients with essential hypertension(EH).Methods EH patients(n=102)admitted in the Nineth Hospital of Xi'an City from Jan.2022 to Oct.2024 were divided,according to left ventricular mass index(LVMI),into observation group[n=54,including EH patients complicated by LVH,LVMI≥95 g/m2(female),LVMI≥115 g/m2(male)],and control group[n=48,including EH patients without LVH,LVMI<95 g/m2(female),LVMI<115 g/m2(male)].The levels of serum NGAL,APN,sST2 and CNP,as well as heart function parameters[left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),heart rate(HR),diastolic blood pressure(DBP),systolic blood pressure(SBP)]were compared between 2 groups.The relationship among the levels of serum NGAL,APN,sST2 and CNP,LVMI and heart function was analyzed,and the value of aforementioned serological parameters was evaluated in predicting LVH in EH.Results The levels of serum NGAL,sST2 and CNP and LVMI were higher,and APN was lower in observation group than those in control group(P<0.05).LVEDD,LVESD,HR,SBP and DBP were higher,and LVEF was lower in observation group than those in control group(P<0.05).In EH patients complicated by LVH,APN was negatively correlated to LVMI(P<0.05),and serum NGAL,sST2 and CNP were negatively correlated to LVEF,and positively correlated to LVMI,LVEDD and LVESD(P<0.05).Serum NGAL has the highest efficacy in predicting LVH in EH.When Youden index reached its maximum,the corresponding cut-off value was 15.32 ng/mL,the area under the curve(AUC)was 0.826,sensitivity was 0.91,and specificity was 0.71.NGAL≥15.32 ng/mL,APN≤10.52 mg/L,sST2≥24.49 ng/L and CNP≥21.99 ng/L were risk factors for LVH occurrence in EH patients(P<0.05).Conclusion The levels of serum NGAL,sST2 and CNP are higher and APN level is lower,and are closely correlated to abnormal heart function,and can be used as indicators to predict LVH in EH patient complicated by LVH.
Keywords：essential hypertensionneutrophil gelatinase-associated lipocalinadiponectinsoluble suppression of tumorigenicity 2C-type natriuretic peptideleft ventricular hypertrophy
Publication Date：2025-11-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：6( 1322-1327 )