Relationship between cardiometabolic index and myocardial infarction section study
CHEN Peng
BAI Jing
LI Huaqing
ZHANG Bin
YANG Lilan
Abstract：Objective To discuss the relationship between cardiometabolic index(CMI)and myocardial infarction(MI)in elderly population.Methods The data were derived from the database of the National Health and Nutrition Examination Survey(NHANES,2011～2018).A cross-sectional study was conducted involving 5132 patients aged 45 years and above.Clinical data such as demographic variables,socioeconomic status,health behaviors,and health status were collected.Patients were divided into non-MI group and MI group based on whether they had experienced MI.The baseline data were compared between 2 groups,and correlation between CMI and MI was assessed by using weighted Logistic regression model with CMI as a continuous variable based on quartiles.Subgroup analysis and mediation analysis were performed on potential covariates to further explore the modifying effect and indirect effect of covariates on the relationship between CMI and MI.Missing data were handled by using multiple imputation.Results Of the 5132 patients,335 had MI,with an incidence rate of 6.53%.The CMI value in MI group was significantly higher than that in non-MI group(0.61 vs.0.52,P<0.001).The results of Logistic regression analysis showed that for each unit increase in CMI,MI risk increased by 16.00%(OR=1.16,95%CI:1.03～1.32,P=0.015).CMI was analyzed by quartiles,and the results showed that patients in the third and fourth quartiles had a significantly increased MI risk compared with those in the lowest quartile.Subgroup analysis revealed a significant correlation between CMI and MI in males,non-Hispanic whites,those who were married or living with a partner,those with an educational level above high school,those with a poverty income ratio≥3.50,former smokers,former drinkers,diabetic patients,those without hypertension,patients with hypercholesterolemia,those with a body mass index(BMI)≥30 kg/m2,those with central obesity,those with a sleep duration<6 hours,and those without physical activity.The results of mediation analysis indicated that smoking,sleep duration,poverty-income ratio,hypertension,hypercholesterolemia,gender,race,diabetes,central obesity,BMI,and age had significant indirect effects on the relationship between CMI and MI,while smoking,poverty-income ratio,hypertension,gender,and age had direct effects on this relationship.Conclusion Elevated CMI is positively correlated to MI risk in middle-aged and older adults,and CMI is valuable for predicting MI occurrence in this population.
Keywords：cardiometabolic indexmyocardial infarctionnational health and nutrition examination surveycross-section study
Publication Date：2025-11-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：7( 1293-1299 )