Introduction to the application of GEPIA database in disease gene expression analysis
CHEN Xinhuan
GENG Hui
HAO Hua
JIANG Hong
MA Mao
Abstract：I n recent years,with the continuous generation of genome sequencing data from a large number of molecular biology laboratories,researchers have been able to interpret the emergence and development of diseases from a molecular perspective,and explore the expression levels of single genes or genomes in diseases.However,the sequence characteristics,expression rules,correlations between genes,and interactions between metabolites contained in genes are very complex,which often makes researchers helpless when they try to the key role of genes in diseases,The emergence of the GEPIA(Gene Expression Proficiency Interactive Analysis)database has effectively solved this problem.The database mainly analyzes TCGA and GTEx data,explores analyzes the expression levels of genes in tumor samples,analyzes the role of genes in tumor production and development,evaluates the co expression levels of genes,and calculates their relationship with tumor prognosis.Through this database,researchers can analyze target genes in a one-stop manner,provide data support for disease treatment targets,achieve accurate disease prognosis classification and diagnosis,fill the gap in the comprehensive information platform of tumor genomics and treatment targets,and promote the application of bioinformatics data in a wide range of research fields.This provides a new perspective for the clinical treatment and diagnosis of diseases.
Keywords：GEPIA databasegene expression analysistumor prognosisbioinformatics
Publication Date：2025-11-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：6( 1287-1292 )