Predictive value of serum MCP-1 and 3-NT levels for adverse cardiac events in patients with acute myocardial infarction after PCI
HUO Xiaowei
PENG Na
ZHANG Fenli
HE Fen
ZHANG Yongjian
Abstract：Objective To evaluate the predictive value of serum monocyte chemoattractant protein-1(MCP-1)and 3-nitrotyrosine(3-NT)concentrations for adverse cardiac events in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 106 patients with AMI admitted to the First Affiliated Hospital of Xi'an Jiaotong University from June 2022 to June 2024 were divided into an events group(n=47)and non-events group(n=59)according to the occurrence of adverse cardiac events.Serum MCP-1,3-NT,and cardiac function indices were compared between groups,and the correlations between these indices and adverse cardiac events were analyzed.Results Compared with the non-events group,MCP-1 and 3-NT levels were significantly higher in the events group(P<0.05).Left ventricular ejection fraction(LVEF)was significantly higher,while left ventricular end-diastolic diameter(LVEDD)and left ventricular end-diastolic area(LVEAD)were significantly higher than in the non-events group(P<0.05).Multivariable analysis showed that a history of heart failure,MCP-1,and 3-NT were independent factors associated with adverse cardiac events after PCI in AMI patients(P<0.05).The area under the receiver operating characteristic(ROC)curve for MCP-1 was 0.869(sensitivity 71.2%,specificity 53.8%),and for 3-NT was 0.786(sensitivity 93.7%,specificity 19.2%).Conclusion Serum MCP-1 and 3-NT levels are independent influencing factors associated with adverse cardiac events in patients with AMI after PCI,and show predictive utility for event occurrence.
Keywords：serum MCP-13-NTacute myocardial infarctionpercutaneous coronary interventionadverse cardiac eventspredictive value
Publication Date：2025-10-20
Online Publishing Date：2025-12-03(First online date of this platform, not the publication date of the document)
Pages：4( 1209-1212 )