Correlation between triglyceride-glucose index and carotid atherosclerotic plaque
LI Xin
YANG Yuhuan
WANG Jun
MA Mao
Abstract：Objective To discuss the relationship between triglyceride-glucose index(TyG)and carotid atherosclerotic plaque(CAP).Methods The cases with physical examinations(n=45 806)were selected from the First Affiliated Hospital of Xi'an Jiaotong University from Jan.2022 to Dec.2023.According to carotid artery ultrasound examination results,the patients were divided into CAP group(n=18 619)and non-CAP group(n=27 187).The general data and laboratory test results were collected in CAP group and non-CAP group.The correlation between TyG as a continuous variable and CAP was analyzed by using single-factor and multi-factor Logistic regression analyses.The adjusted models included sex,age,body mass index(BMI),waist circumference,blood lipids,blood pressure(BP),uric acid(UA),creatinine(Cr),estimated glomerular filtration rate(eGFR),and smoking rate.According to TyG quartiles,the cases were divided into Q1 group(TyG<7.247),Q2 group(7.247≤TyG≤7.663)、Q3 group(7.664≤TyG≤8.095)and Q4 group(TyG≥8.096).The incidence of CAP was compared among groups Q1～Q4.Results TyG was significantly higher in CAP group than that in non-CAP group(7.85±0.64 vs.7.61±0.65,P<0.001).Compared to non-CAP group,CAP group had higher proportions of males,as well as higher age,BMI,waist circumference,systolic blood pressure(SBP),diastolic blood pressure(DBP),UA,fasting blood glucose(FBG),total cholesterol(TC),low-density lipoprotein(LDL),triglycerides(TG),smoking rate and Cr levels,while eGFR and high-density lipoprotein cholesterol(HDL-C)levels were lower,with statistically significant differences(P<0.001).The results of Multi-factor linear regression analysis showed that TyG was correlated to CAP after adjusting for multiple confounding factors.For every 1-unit increase in TyG,there was a positive correlation with CAP incidence(unadjusted OR=1.775,95%CI:1.723～1.829;fully adjusted OR=1.063,95%CI:1.004～1.125).The results of grouping according to TyG quartiles showed that as TyG increased,CAP detection rate progressively rose,with detection rates of 26.35%,39.23%,46.92%,and 50.09%in groups Q1～Q4,respectively.Conclusion TyG is positively correlated to CAP,which is independent of traditional cardiovascular risk factors.
Keywords：triglyceride-glucose indexcarotid atherosclerotic plaquecardiovascular risk
Publication Date：2025-10-20
Online Publishing Date：2025-12-03(First online date of this platform, not the publication date of the document)
Pages：5( 1204-1208 )