Influence of ticagrelor on vascular endothelial function and oxidative stress indicators in patients with coronary heart disease underwent percutaneous coronary intervention
Zhang Peiyong
Guo Yonglong
Li Hongjun
Abstract：Objective To investigate the influence of ticagrelor on vascular endothelial function and oxidative stress indicators in patients with coronary heart disease(CHD)underwent percutaneous coronary intervention(PCI).Methods CHD patients underwent(n=180)were selected and divided randomly into clopidogrel group(treated with aspirin+clopidogrel)and ticagrelor group(treated with aspirin+ticagrelor,each n=90)in Department of Cardiovascular Medicine of the First Affiliated Hospital of Xinxiang Medical College from Mar.2022 to Mar.2023.The changes of vascular endothelial function[nitric oxide(NO),von Willebrand factor(vWF),endothelin-1(ET-1)],inflammatory factors[high sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),soluble CD40 ligand(sCD40L)]and oxidative stress indicators[superoxide dismutase(SOD),glutathione peroxidease(GPx),malondialdehyde(MDA)],clinical efficacy and occurrence of major adverse cardiovascular events(MACE,bleeding,ischemia,re-infarction,thrombosis)were observed in 2 groups.Results After treatment,NO increased(P＜0.05),and vWF and ET-1 decreased(P＜0.05)in 2 groups,and NO was higher(P＜0.05),and vWF and ET-1 were lower in ticagrelor group than those in clopidogrel group(P＜0.05).After treatment,hs-CRP,IL-6 and sCD40L decreased(P＜0.05)in 2 groups,and hs-CRP,IL-6 and sCD40L were lower in ticagrelor group than those in clopidogrel group(P＜0.05).After treatment,SOD and GPx increased(P＜0.05),MDA decreased(P＜0.05),and SOD and GPx were higher(P＜0.05),and MDA was lower in ticagrelor group than those in clopidogrel group(P＜0.05).The total effective rate was 93.33%in ticagrelor group and 82.22%in clopidogrel group(P＜0.05).The incidence of MACE was 4.44%in ticagrelor group and 14.44%in clopidogrel group(P＜0.05).Conclusion Ticagrelor,as an adjuvant drug for CHD after PCI,can effectively improve vascular endothelial function,relieve inflammatory and oxidative stress reactions,promote clinical efficacy,and reduce MACE incidence.
Keywords：TicagrelorCoronary heart diseasePercutaneous coronary interventionVascular endothelial functionOxidative stress indicatorsInflammatory factors
Publication Date：2025-09-20
Online Publishing Date：2025-11-04(First online date of this platform, not the publication date of the document)
Pages：4( 1073-1076 )