Relationship between erythropoietin and mean platelet volume at admission and long-term prognosis in patients with coronary heart disease after percutaneous coronary intervention
Yang Hongying
Lu Weixing
Wang Kun
Han Lantang
Zhang Yin
Abstract：Objective To observe the relationship between erythropoietin(EPO)and mean platelet volume(MPV)at admission and long-term prognosis in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods CHD patients(n=112)were selected and divided,according their prognosis,into good prognosis group(n=84)and poor prognosis group(n=28)at Department in Cardiology of People's Hospital of Beijing Daxing District from Jan.2021 to Dec.2022.MPV was detected by using full-automatic blood analyzer,and EPO was detected by using enzyme-linked immunosorbent assay(ELISA).The influence factors on CHD prognosis were analyzed by using multi-factor Logistics regression analysis,and predictive value of EPO and MPV to long-term prognosis was analyzed based on ROC curve analysis.Results The number of diseased coronary vessels,left ventricular ejection fraction(LVEF)＜40%and Gensini integrals were significantly lower in good prognosis group than those in poor prognosis group(P＜0.05).The differences in other clinical baseline data had no statistical significance between 2 groups(P＞0.05).The major adverse cardiovascular event(MACE)wwas post-PCI angina pectoris(35.71%)in poor prognosis group.EPO and MPV at admission were significantly lower in good prognosis group than those in poor prognosis group(P＜0.05).The number of diseased coronary vessels,LVEF＜40%,EPO＞8.91 mU/L and MPV＞9.23 fl were independent risk factors for MACE occurrence in CHD patients after PCI(P＜0.05).The probability by risk prediction model was as follow:P=1/[1+e(-4.296+1.257×(number of diseased coronary vessels)+1.288×(LVEF)+1.207×(EPO)+1.239×(MPV)].The AUC of EPO combined with MPV was 0.918 in predicting MACE,sensitivity was 92.86%and specificity was 76.19%.AUC and sensitivity were the highest.Conclusion EPO and MPV at admission are correlated to long-term prognosis in CHD patients after PCI.
Keywords：ErythropoietinMean platelet volumeCoronary heart diseasePercutaneous coronary interventionLong-term prognosis
Publication Date：2025-08-20
Online Publishing Date：2025-10-24(First online date of this platform, not the publication date of the document)
Pages：4( 1007-1010 )