Regulation and possible mechanisms of paraventricular nucleus of hypothalamus to ventricular stability after myocardial infarction
Gao Meng
Tian Guoxiang
Yin Dechun
Chen Jugang
Wu Yuntao
Abstract：Objective To prove the regulating effect of paraventricular nucleus of hypothalamus(PVN)on electrical stability of infarcted myocardium,and observe the physiological and pathological changes of PVN during myocardial infarction(MI).Methods ①Male SD rats(n=36)were selected and randomly divided into 3 groups(each n=12).Acute myocardial infarction(AMI)was induced through ligating the anterior descending coronary artery in all rats.After 24 h,PVN was stimulated by 0 mA,1.2 mA and 3 mA,respectively,in 3 groups.The incidence of ventricular arrhythmias(VA)and atrial arrhythmia were observed.②Male SD rats(n=24)were selected and divided into sham-operation group and MI group.The myocardial electrophysiological activity was detected in 2 groups,and gliacyte activation in PVN and level of interleukin-6(IL-6)were observed in 2 groups.Results ①There was typical arrhythmia occurred after stimulating PVN,VA incidence was 91.6%and incidence of atrial arrhythmias was 16.6%(P＜0.05).②The threshold of ventricular fibrillation was 8.0 V in sham-operation group and 7.5V in MI group(P＜0.05).③The level of IL-6 in PVN was significantly higher in MI group than that in control group(P＜0.05).The activations of small gliacytes and astrocytes(Ast)in PVN were more significant in MI group than those in sham-operation group(P＜0.05).Conclusion PVN is a regulation center for controlling ventricular stability after MI,and the mechanism may be related to IL-6 increase induced by gliacyte activation.
Keywords：Myocardial infarctionNerve regulationParaventricular nucleus of hypothalamusInterleukin-6Rats
Publication Date：2025-08-20
Online Publishing Date：2025-10-24(First online date of this platform, not the publication date of the document)
Pages：5( 997-1000,1006 )