Relationship between changes of soluble suppression of tumorigenicity 2 and growth differentiation factor-15 and myocardial remodeling in patients with chronic heart failure and different heart function grades
Sun Xiaowei
Gao Wei
Jiang Xiaoying
Abstract：Objective To investigate the relationship between level changes of serum soluble suppression of tumorigenicity 2(sST2)and growth differentiation factor-15(GDF-15)and myocardial remodeling in patients with chronic heart failure(CHF)with different NYHA grades of heart function.Methods CHF patients(n=125)were selected into case group,and healthy volunteers(n=110)were selected into control group in Qingdao Municipal Hospital from Oct 2021 to Oct.2023.The level changes of serum sST2,GDF-15 and red blood count(RBC),and myocardial remodeling[left ventricular end-diastolic diameter(LVEDD),left atrial diameter(LAD),left ventricular posterior wall thickness(LVPWT),left ventricular mass index(LVMI),left ventricular remodeling index(LVRI)]were analyzed.The relationship between changes of sST2 and GDF-15 and myocardial remodeling was analyzed.Results The levels of sST2 and GDF-15 were significantly higher in case group than those in control group(P＜0.05).The levels of LVEDD,LAD,LVPW and LVMI were significantly higher,and LVRI was significantly lower in case group than those in control group(P＜0.05).The levels of sST2,GDF-15,LVEDD,LAD,LVPW and LVMI were significantly lower,and LVRI was significantly higher in patients with NYHA grades I and II than those in patients with NYHA grades Ⅲ and Ⅳ.The levels of sST2,GDF-15,LVEDD,LAD,LVPW and LVMI were significantly lower,and LVRI was significantly higher in patients with NYHA grade Ⅲ than those in patients with NYHA gradeⅣ(P＜0.05).The results of correlation analysis showed that sST2 and GDF-15 were positively correlated to LVEDD,LAD,LVPW and LVMI,and negatively correlated to LVRI(P＜0.05).Conclusion The levels of serum sST2 and GDF-15 are positively correlated to NYHA heart function grades,and level changes of serum sST2 and GDF-15 are closely related to myocardial remodeling.
Keywords：Heart function gradesChronic heart failureSoluble suppression of tumorigenicity 2Growth differentiation factor-15Myocardial remodeling
Publication Date：2025-08-20
Online Publishing Date：2025-10-24(First online date of this platform, not the publication date of the document)
Pages：4( 993-996 )