Correlation between neutrophil percentage to albumin ratio and prognosis in elderly patients with heart failure
Guo Yuanyuan
Wang Jing
Zhang Lihui
Abstract：Objective To relationship between neutrophil percentage to albumin ratio(NPAR)and poor prognosis in elderly patients with heart failure(HF).Methods The elderly HF patients(n=1683)were selected from HF database,and divided,according to NPAR tertiles,into T1 group(NRAR＜18.95),T2 group(18.95≤NPAR＜22.45)and T3 group(NPAR≥22.45).The data were analyzed by using SPSS 27.0 and R4.2.2 statistical software,and relationship between NPAR and all-cause mortality was analyzed in elderly HF patients after 28 d,3 months and 6 months.The dose-response relationship between NPAR and the prognosis was reviewed by using restricted cubic spline(RCS)plots.A subgroup analysis was conducted to determine the consistency of correlation between NPAR and 28-day mortality across different populations.The predictive effects of NPAR,neutrophil percentage and albumin(ALB)were reviewed by using ROC curves.Results The results of Multi-factor Logistic regression analysis revealed that for each unit increased in NPAR,the risk of all-cause mortality increased,respectively,by 8.8%,8.2%,and 6.4%at 28 d(OR=1.088,95%CI:1.022～1.157),3 months(OR=1.082,95%CI:1.020～1.148)and 6 months OR=1.064,95%CI:1.009～1.123,P＜0.05).Taken T1 group as reference group,T3 group exhibited the highest mortality risk at 28 d(OR=5.692,95%CI:1.537～21.080),3 months(OR=3.621,95%CI:1.253～10.460),and 6 months(OR=3.237,95%CI:1.304～8.041,P＜0.05).The results of RCS analysis showed that NPAR positively correlated to all-cause mortality at 28 d,3 months and 6 months(P-nonlinear＞0.05).There was no interactive effect among subgroup factors,NPAR and 28-d all-cause mortality(P for interaction＞0.05).The results of ROC curve analysis showed that,in predicting 28-d all-cause mortality,AUC of NPAR was 0.719(95%CI:0.634～0.805),AUC of neutrophil percentage was 0.687(95%CI:0.598～0.776),and AUC of ALB was 0.672(95%CI:0.586～0.759,P＜0.05).Conclusion High NPAR is an independent risk factor for all-cause mortality,and NPAR has a higher value in predicting all-cause mortality compared with neutrophil percentage and ALB in elderly HF patients.
Keywords：Heart failureNeutrophil percentageAlbuminPrognosisAll-cause mortality
Publication Date：2025-08-20
Online Publishing Date：2025-10-24(First online date of this platform, not the publication date of the document)
Pages：6( 957-962 )