Predictive value of systemic immune inflammation index to long-term major adverse cardiovascular and cerebrovascular events in patients with acute myocardial infarction
Wang Zhiwen
Wu Si
Cai Dongdong
Ma Heng
Ma Chao
Xu Yize
Fei Jinlei
Hu Min
Gao Xinchun
Abstract：Objective To discuss the predictive value of systemic immune inflammation index(SII)to long-term major adverse cardiovascular and cerebrovascular events(MACCE)in patients with acute myocardial infarction(AMI).Methods AMI patients were continuously selected and completed revascularization(CR)during hospitalization or within one month in Department of Cardiology at Shuyang Hospital affiliated to Xuzhou Medical University from Feb.2020 to Feb.2023.The patients were followed up to determine whether MACCE occurred in the long term after CR,they were divided into MACCE group(n=124)and non-MACCE group(n=398).The clinical data were analyzed in 2 groups,and Logistic regression analysis was used to screen for risk factors of MACCE events in the patients.The ability of SII to predict MACCE was reviewed by using ROC curve.Results The percentages of hypertension and new-onset atrial fibrillation(NOAF),platelet count,SII,C-reactive protein(CRP),aspartate aminotransferase(AST),brain natriuretic peptide(BNP),left atrial diameter(LAD)and left ventricular end-diastolic diameter(LVEDd)were significantly higher(P＜0.05),while percentages of male and smoking,hemoglobin(HGB),glomerular filtration rate(eGFR)and triglyceride(TG)were significantly lower in MACCE than those in non-MACCE group(P＜0.05).The results of multi-factor Logistic regression analysis showed that higher eGFR was a protective factor for MACCE(P＜0.05),and NOAF and SII were independent risk factors for MACCE(P＜0.05)in AMI patients after CR.SII was the strongest predictor for MACCE occurrence(OR=1.003,95％CI:1.002～1.003,P＜0.001).The results of ROC curve analysis showed that,in predicting MACCE in AMI patients,AUC of SII was 0.852(95％CI:0.816～0.889,P＜0.001),optimal cut-off value based on the Jordon's index was 802.77,sensitivity was 87.9％and specificity was 69.6％.Conclusion A higher SII is one of the independent predictors of long-term MACCE in AMI patients.Identifying high-risk patients and optimizing treatment strategies can help improve patient prognosis.
Keywords：Acute myocardial infarctionPercutaneous coronary interventionSystemic immune inflammation indexMajor adverse cardiovascular and cerebrovascular events
Publication Date：2025-07-20
Online Publishing Date：2025-09-09(First online date of this platform, not the publication date of the document)
Pages：5( 870-873,877 )