Correlation among lipoprotein a,neutrophil to high-density lipoprotein-cholesterol ratio and severity of coronary artery lesions of premature coronary artery disease
Li Linan
Jia Lu
He Wei
Ban Xinquan
Heng Mingqiang
Yang Yanru
Dong Liyuan
Wang Huan
Wang Mao
Abstract：Objective To discuss the correlation among lipoprotein a[Lp(a)],neutrophil to high-density lipoprotein-cholesterol ratio(NHR)and severity of coronary artery lesions in patients with premature coronary artery disease(PC AD).Methods PC AD patients underwent coronary angiography(n=781)were retrospectively analyzed in People's Hospital of Changji Prefecture from Jan.2020 to Dec.2023.According to SYNTAX scores,the patients were divided into low-risk group(n=686),mid-risk group(n=60)and high-risk group(n=35).The basic clinical data,NHR and Lp(a)were compared among 3 groups.The risk factors of PCAD were screened by using Spearman rank correlation analysis and ordered multi-factor Logistic regression analysis.The predictive value of Lp(a)and NHR to severity of coronary artery lesions of PCAD was reviewed by using ROC curve.Results There were statistical differences in drinking history,type 2 diabetes mellitus(T2DM),neutrophil count(NEUT),NHR,high-density lipoprotein-cholesterol(HDL-C),low-density lipoprotein-cholesterol(LDL-C),apolipoprotein A1(ApoA1),apolipoprotein B(ApoB)and Lp(a)among 3 groups(P＜0.05).The levels of NHR,NEUT,ApoB,LDL-C and Lp(a)were higher(P＜0.05),and levels of HDL-C and Apo A1 were lower(P＜0.05)in high-risk group than those in low-risk group.There was a statistically significant difference in cumulative number of coronary lesion vessels among 3 groups(P＜0.05).The left anterior descending artery had the highest proportion in all 3 groups,and proportions of left anterior descending artery,circumflex artery and right coronary artery all showed an increasing trend with the elevation of SYNTAX scores(P＜0.001).The results of Spearman rank correlation analysis showed that NHR,Lp(a)and T2DM were positively correlated to SYNTAX scores.The results of ordered multi-factor Logistic regression analysis showed that Lp(a),NHR and T2DM were risk factors for severe coronary artery lesions of PC AD.The results of ROC curve analysis showed that,in predicting severity of coronary artery lesions of PCAD,AUC of Lp(a)was 0.657(95％CI:0.580～0.734),AUC of NHR was 0.681(95％CI:0.592～0.770),and AUC of Lp(a)combined with NHR was 0.696(95％CI:0.607～0.786,P＜0.001).Conclusion Lp(a)and NHR are correlated to severity of coronary artery lesions of PCAD,and combination of both has some diagnostic efficiency to severe coronary artery lesions of PCAD.
Keywords：Premature coronary artery diseaseLipoprotein aNeutrophilHigh-density lipoprotein-cholesterolLow-density lipoprotein-cholesterol
Publication Date：2025-07-20
Online Publishing Date：2025-09-09(First online date of this platform, not the publication date of the document)
Pages：6( 824-829 )