Relationship among ratio of high-density lipoprotein-cholesterol to low-density lipoprotein-cholesterol,ratio of blood urea nitrogen to creatinine and prognosis in patients with acute exacerbation of chronic heart failure
Wang Fang
Liu Xiuhong
Yang Xiaoli
Xiong Zhenzhen
Fan Hongxia
Abstract：Objective To explore the relationship among ratio of high-density lipoprotein cholesterol to low-density lipoprotein cholesterol(HDL-C/LDL-C),ratio of blood urea nitrogen to creatinine(BUN/Cr)and prognosis in patients with acute exacerbation of chronic heart failure(CHF).Methods A total of 340 patients with acute exacerbation of CHF were selected in Chengdu West District Hospital from July 2020 to July 2023.They were followed up for 6 months and divided into a good prognosis group and a poor prognosis group according to whether they had adverse cardiovascular events.The clinical data,levels of HDL-C/LDL-C and BUN/Cr were compared between 2 groups.The diagnostic value of HDL-C/LDL-C and BUN/Cr to prognosis was analyzed through plotting receiver operating characteristic(ROC)curves,and risk factors for poor prognosis were analyzed by using multi-factor Logistic regression.Results Of the 340 patients,25 were lost to follow-up,and remaining 315 completed the follow-up.Among them,83 cases(24.41％)had a poor prognosis,and 232 cases(75.59％)had a good prognosis.There were no statistically significant differences in terms of age,gender,disease duration,history of hypertension,history of diabetes,cardiomyopathy,smoking history,drinking history,or proportion of diastolic blood pressure(DBP)between 2 groups(P＞0.05).The proportion of NYHA class Ⅳ,left ventricular ejection fraction(LVEF)and systolic blood pressure(SBP)were all lower in good prognosis group than those in poor prognosis group(P＜0.05).HDL-C/LDL-C was higher and BUN/Cr was lower in good prognosis group than those in poor prognosis group(P＜0.05).The AUC values of HDL-C/LDL-C and BUN/Cr were 0.595 and 0.909,respectively,both lower than the AUC value of 0.915 for their combined diagnosis(P＜0.05).The results of Logistic regression analysis showed that a high proportion of NYHA class Ⅳ,a low HDL-C/LDL-C and a high BUN/Cr were risk factors for poor prognosis(P＜0.05).Conclusion HDL-C/LDL-C and BUN/Cr are risk factors for poor prognosis in CHFpatients.They have high efficacy in predicting poor clinical prognosis and thus possess good clinical application value.
Keywords：Chronic heart failureRatio of high-density lipoprotein-cholesterol to low-density lipoprotein-cholesterolRatio of blood urea nitrogen to creatininePrognosis
Publication Date：2025-07-20
Online Publishing Date：2025-09-09(First online date of this platform, not the publication date of the document)
Pages：4( 820-823 )