Pyroptosis of coronary artery disease:A study based on CiteSpace and VOSviewer
Liu Min
Chen Keji
Wang Peili
Ma Xiaojuan
Abstract：Objective In recent years,research on pyroptosis in coronary artery disease(CAD)has been emerging continuously.To explore the global research status,hotspots,and development trends in this field,a statistical analysis and evaluation of related studies were conducted by using bibliometric methods,aiming to provide references for future research.Methods The literature on pyroptosis of coronary artery disease were retrieved in databases of CNKI and Web of Science Core Collection from 2004 to 2023,and a visual analysis of the literature was conducted by using Citespace,VOSviewer and Scimago Graphica software.Results A total of 1761 articles were selected,including 605 Chinese articles and 1156 English articles.The visual analysis reveals that the number of publications in this field has shown a year-on-year increasing trend.China is the country with the highest publication output,while the United States exhibits the strongest collaboration intensity with other nations.Virginia Commonwealth University and Shandong University are the prominent research institutions in this field.Research teams led by core representatives such as Du Guanhua,Hu Longjiang,Zhang Weichao,Abbate Antonio,Toldo Stefano,and Mezzaroma Eleonora have made significant contributions to the field.Keyword analysis suggests that research on the pathological mechanisms of pyroptosis in coronary artery disease continues to attract sustained attention,and Myocardial infarction and myocardial ischemia-reperfusion injury remain hotspots in this field.The use of pharmacological strategies to inhibit pyroptosis-related inflammatory signaling is currently a major research focus.Additionally,studies on traditional Chinese medicine mechanisms for improving coronary artery disease by suppressing pyroptosis are gradually gaining prominence.Conclusion Targeting the signaling pathway of pyroptosis of coronary artery is a novel therapeutic target for coronary artery disease,which can provide more insights into clinical treatments and offer new strategies for developing coronary artery drugs.
Keywords：Coronary artery diseasePyroptosisCitespaceVOSviewerBibliometrics
Publication Date：2025-07-20
Online Publishing Date：2025-09-09(First online date of this platform, not the publication date of the document)
Pages：5( 769-773 )