Application of Engineered Exosomes in Ischemic Heart Disease
Abstract：Ischemic heart disease (IHD) is a major disease that threatens human health [1]. Studies have shown that mesenchymal stem cells (MSCs) are multipotent and, when transplanted into ischemic hearts, can differentiate into endothelial cells, vascular smooth muscle cells, and even cardiomyocyte-like cells. However, reduced survival rate and embolism risk are the main limitations of MSC therapy for IHD. Subsequent studies suggest that MSCs mainly exert cardioprotective effects through paracrine mechanisms. MSC-derived exosomes may become a new alternative approach for the treatment of IHD [2].
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Publication Date：2025-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 754-758 )