Risk factors for atrial fibrillation in patients with heart failure with preserved ejection fraction
Huang Junhui
Wang Minying
Chen Ruifang
Miao Bo
Abstract：Objective To analyze the risk factors for atrial fibrillation(AF)in patients with heart failure with preserved ejection fraction(HFpEF).Methods HFpEF patients(n=120)were selected and divided into AF group(n=46)and non-AF group(n=74)from Central Hospital of Xingtai City from Mar.2022 to Oct.2024.The risk factors for HFpEF complicated by AF were discussed.The predictive value of left ventricular ejection fraction(LVEF),uric acid(UA)and N-terminal pro-brain natriuretic peptide(NT-proBNP)to HFpEF complicated by AF was analyzed.Results The results of multi-factor Logistic regression analysis showed that pulmonary arterial hypertension(PAH,OR:3.158,95%CI:1.449～6.881),NYHA classification of heart function(OR:4.337,95%CI:1.397～13.462),LVEF(OR:0.590,95%CI:0.491～0.709),UA(OR:1.052,95%CI:1.033～1.071),and NT-proBNP(OR:1.006,95%CI:1.003～1.008)all were risk factors for HFpEF complicated by AF(P＜0.05).In prediction of HFpEF complicated by AF with combination of LVEF,UA and NT-proBNP,AUC was 0.982,sensitivity was 93.20%,and specificity was 93.50%,which were all higher than that of each indicator alone.Conclusion The risk factors for HFpEF complicated by AF include PAH,NYHA classification of heart function,LVEF,UA and NT-proBNP.The combination of LVEF,UA and NT-proBNP has a higher diagnostic value in predicting HFpEF complicated by AF.
Keywords：Heart failure with preserved ejection fractionAtrial fibrillationRisk factorsPulmonary arterial hypertensionUric acid
Publication Date：2025-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 724-726 )