Relationship among microRNA-27a-3p,activating transcription factor 3 and poor prognosis in patients with acute myocardial infarction after percutaneous coronary intervention
Yang Qin
Zhang Huayong
Zhang Yuanjie
Zhao Peng
Abstract：Objective To discuss the relationship among microRNA-27a-3p(miR-27a-3p),activating transcription factor 3(ATF3)and poor prognosis in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods AMI patients underwent PCI(n=112)were selected AMI group from Qilu Hospital&Dezhou Hospital of Shandong University from Jan.2021 to June 2022.The patients in AMI group were divided,according to occurrence of major adverse cardiovascular events(MACE)after PCI,into MACE group(n=22)and non-MACE group(n=90),and meanwhile healthy volunteers with physical examination(n=54)were selected into control group.The levels of serum miR-27a-3p and ATF3 were detected by using,respectively,real-time fluorescence quantitative polymerase chain reaction(qRT-PCR)and enzyme-linked immunosorbent assay(ELISA).The targeting relationship between miR-27a-3p and ATF3 was predicted by applying Target Scan Human website.The influence factors for postoperative MACE occurrence in AMI patients were investigated by using Logistic regression analysis,and correlation between miR-27a-3p and ATF3 was analyzed by using Pearson correlation analysis.The predictive value of levels of serum miR-27a-3p and ATF3 to postoperative MACE occurrence in AMI patients by using ROC curve.Results The level of miR-27a-3p increased significantly,and ATF3 level decreased significantly in AMI group compared with those in control group(P＜0.05).The level of miR-27a-3p and percentage of multi-vessel lesions were higher,and ATF3 level was lower in MACE group than those in non-MACE group(P＜0.05).The multi-vessel lesions and miR-27a-3p level were risk factors for poor prognosis,and ATF3 level was a protective factor(P＜0.05).The level of miR-27a-3p was negatively correlated to ATF3 level(P＜0.05),there was a targeting relationship between them.In predicting poor prognosis,miR-27a-3p combined with ATF3 was superior to miR-27a-3p(Z=2.124,P=0.033)alone or ATF3(Z=1.974,P=0.048)alone.Conclusion The level of miR-27a-3p increases and ATF3 level decreases in AMI patients,and serum miR-27a-3p and ATF3 have some predictive value to poor prognosis in AMI patients after PCI.
Keywords：Acute myocardial infarctionPercutaneous coronary interventionActivating transcription factor 3MicroRNA-27a-3p
Publication Date：2025-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 719-723 )