Expressions and significance of microRNA and NOD-like receptor thermal protein domain-associated protein 3 in peripheral blood in patients with acute myocardial infarction
Hao Cuijun
Wang Rui
Ma Yiping
Zhang Xueping
Liu Yanan
Qin Shaoqiang
Abstract：Objective To analyze the expressions and significance of microRNA-55(miR-55)and NOD-like receptor thermal protein domain-associated protein 3(NLRP3)in peripheral blood in patients with acute myocardial infarction(AMI).Methods AMI patients were selected into AMI group(n=280)and healthy persons with physical examination were selected into control group(n=150)from Department of Cardiovascular Medicine in the First Affiliated Hospital of Hebei North University from Jan.2022 to Dec.2023.The levels of miR-155,NLRP3 and myocardial injury biomarkers[brain natriuretic peptide(BNP),cardiac troponin I(cTnⅠ),creatine kinase-MB isoenzyme(CK-MB)]were compared between 2 groups.The correlation among miR-155,NLRP3,BNP,cTnⅠ and CK-MB was analyzed.The patients were followed up for 6 months,and divided,according to occurrence of major adverse cardiovascular events(MACE),into MACE group(n=48)and non-MACE group(n=232).The influence factors for MACE occurrence,and predictive value of miR-155 and NLRP3 to MACE occurrence were analyzed in AMI patients.Results The levels of miR-155,NLRP3,BNP,cTnⅠ and CK-MB were higher in AMI group than those in control group(P＜0.05).The results of Pearson correlation analysis showed that miR-155 and NLRP3 in peripheral blood were positively correlated to BNP,cTnⅠ and CK-MB(P＜0.05).The results of multi-factor Logistic regression analysis showed that age ≥ 60(OR=2.038,95％CI:1.309～3.174),diabetes history(OR=1.923,95％CI:1.320～2.802),poor medication compliance(OR=2.115,95％CI:1.285～3.479),higher miR-155 expression(OR=2.109,95％CI:1.257～3.538),and increased NLRP3(OR=2.071,95％CI:1.312～3.270),BNP(OR=1.982,95％CI:1.321～2.973),cTnⅠ(OR=1.996,95％CI:1.299～3.066)and CK-MB(OR=2.081,95％CI:1.290～3.358)were risk factors for MACE occurrence in AMI patients(P＜0.05).The results of ROC curve analysis showed that AUC of miR-155 was 0.854,AUC of NLRP3 was 0.886,and AUC of combination of miR-155 and NLRP3 was 0.958(P＜0.05).Conclusion The expressions of miR-155 and NLRP3 in peripheral blood are higher,which is closely correlated to myocardial injury and MACE occurrence in AMI patients.
Keywords：Acute myocardial infarctionMicroRNA-55NOD-like receptor thermal protein domain-associated protein 3Myocardial injuryMajor adverse cardiovascular events
Publication Date：2025-05-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 616-620 )