Research Progress on Hypertension-Induced Cardiovascular Lesions Based on Vascular Endothelium
Abstract：Hypertension is the main cause of cardiovascular diseases [1, 2]. Hypertension is often accompanied by vascular endothelial dysfunction, which mutually influences and causes each other. With the aggravation of population aging, the prevalence of hypertension has been increasing year by year. Patients have poor compliance with clinical treatment, and blood pressure control is unsatisfactory, thereby affecting vascular endothelial function. The elastic capacity of endothelial cells decreases, and their antioxidant, anti-inflammatory, antithrombotic, and vascular contraction and dilation functions are impaired. This leads to an imbalance in the vascular internal environment, resulting in endothelial dysfunction, which ultimately induces the occurrence of cardiovascular diseases such as pulmonary hypertension, myocardial infarction, atherosclerosis, and heart failure, reducing people's quality of life and increasing the burden on the public health system. This article summarizes the current understanding of hypertension and reviews the latest research on the pathogenesis of cardiovascular lesions induced by vascular endothelial dysfunction, aiming to provide new insights for the treatment of cardiovascular diseases related to endothelial dysfunction.
Machine-generated Keywords：
Publication Date：2025-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 510-512 )