Value of sakubatril-valsartan to acute anterior myocardial infarction after PCI based on changes of ven-tricular strain and myocardial injury biomarkers
Li Xuehua
Xu Liqiong
Huang Jian
Han Qian
Abstract：Objective To investigate the therapeutic value of akubatril-valsartan to acute anterior myocardial infarction(AAMI)I based on changes of ventricular strain and myocardial injury biomarkers after percutaneous coronary intervention(PCI).Methods AAMI patients(n=140)underwent PCI were selected from Jan.2019 to Jan.2024,and divided into observation group treated with akubatril-valsartan combined with atorvastatin calcium,and control group treated with atorvastatin calcium(n=70).The indexes of myocardial injury[brain natriuretic peptide(BNP),creatine kinase isoenzyme(CK-MB),creatine kinase(CK)and cardiac troponin I(cTnI)]were detected by using automatic biochemical analyzer.The indexes of heart function[left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),cardiac output(CO),heart rate]were detected by using Doppler color diasonograph and electrocardiogram.The indexes of ventricular strain[left atrial systolic peak longitudinal strain(LAS-S)and strain rate(LASR-S),left atrial early diastole peak longitudinal strain(LAS-E)and strain rate(LASR-E),left atrial late diastolic longitudinal peak strain(LAS-A)and strain rate(LASR-A)]were detected by using speckle tracking imaging.The adverse reactions and postoperative complications were recorded and analyzed during treatment.The curative effect was evaluated in 2 groups after treatment for 2 months.Results Before treatment,the differences in BNP,cTnI,CK-MB,CK,LVEF,LVEDD,CO,heart rate,LAS-S,LASR-S,LAS-E,LASR-E,LAS-A and LASR-A had no statistical significance between 2 groups(P＞0.05).After treatment,BNP,cTnI,CK-MB and CK decreased significantly in 2 groups(P＜0.05),and were lower in observation group(P＜0.05).After treatment,LVEDD and heart rate were lower,and CO and LVEF were higher in 2 groups(P＜0.05),which were more significant in observation group(P＜0.05).After treatment,LAS-S,LASR-S,LAS-E and LASR-E were higher,and LAS-A and LASR-A were lower(P＜0.05)in 2 groups,which were more significant in observation group(P＜0.05).The difference in adverse reaction incidence had no statistical significance between 2 groups(P＞0.05).The incidence of complications after PCI(heart failure,arrhythmia,thrombosis,vascular hematoma,vascular bleeding)was lower in observation group than that in control group(P＜0.05),and clinical effective rate was higher in observation group than that in control group(94.29%vs.82.86%,P＜0.05).Conclusion The comprehensive value of akubatril-valsartan combined with atorvastatin calcium is higher than that of atorvastatin calcium alone in AAMI patients after PCI.This combination can reduce myocardial injury,alleviate ventricular strain,improve heart function,and has fewer complications with good safety.It provides a more reliable treatment option for AAMI patients after PCI.
Keywords：Sakubatril-valsartanAcute anterior myocardial infarctionPercutaneous coronary interventionVentricular strainMyocardial injury biomarkers
Publication Date：2025-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 427-431 )