Predictive value of systemic immune inflammation index combined with uric acid to high-density lipoprotein-cholesterol ratio to contrast-induced acute kidney injury in patients with acute myocardial in-farction after percutaneous coronary intervention
Wang Linsheng
Zhang Xudong
Jin Jingkun
Ding Jiahui
Li Wenhua
Abstract：Objective To investigate the predictive value of systemic immune inflammation index(SII)combined with uric acid to high-density lipoprotein-cholesterol ratio(UHR)to contrast-induced acute kidney injury(CI-AKI)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods AMI patients(n=1222)underwent PCI were selected from Department of Cardiology in Affiliated Hospital of Xuzhou Medical University from Jan.2020 to May 2023.The influencing factors of CI-AKI were analyzed and screened in AMI patients after PCI,and a nomogram model was established.The receiver operating characteristic(ROC)curve was drawn to review the predictive value of SII,UHR and their combination for CI-AKI after PCI.Results Diabetes(OR=3.338,95%CI:2.019～5.524),cystatin C(OR=2.438,95%CI:1.094～5.632),diuretics(OR=4.042,95%CI:2.360～7.199),UHR(OR=1.004,95%CI:1.002～1.006)and LnSII(OR=2.358,95%CI:1.677～3.361)were independent influence factors for CI-AKI occurrence in AMI patients after PCI.The results of ROC curve analysis showed that,in prediction of CI-AKI occurrence in AMI patients after PCI,AUC of UHR combined with SII was 0.761(95%CI:0.709～0.812),which was better than that of UHR or SII alone.Conclusion High SII and high UHR are risk factors for AMI,and their combination can improve the accuracy of predicting CI-AKI in AMI patients after PCI.
Keywords：Systemic immune inflammation indexContrast-induced acute kidney injuryAcute myocardial infarctionPercutaneous coronary intervention
Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 351-355 )