Correlation among hs-CRP,homocysteine,blood lipid and TCM pattern differentiation and classification of essential hypertension:a Meta-analysis
Zhang Ruina
Tao Qingchun
Nai Jing
Abstract：Objective To investigate the correlation among serum high sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy),blood lipid and TCM pattern differentiation and classification(patterns of phlegm-damp accumulation,hyperactive liver fire,yin deficiency with yang hyperactivity and dual deficiency of yin and yang)of essential hypertension(EH)based on a Meta-analysis,and to provide reference for objectification of TCM pattern differentiation for EH.Methods The databases of CNKI,CBM,VIP,WanFang Data and PubMed were retrieved from Jan 2015 to Apr.2024.The published studies on the correlation among TCM patterns of EH and serum hs-CRP,Hcy and blood lipids were collected,and literature that meets the criteria were screened based on inclusion and exclusion standards.All literature were given methodological quality evaluation based on standard of Newcastle-Ottawa Scale(NOS),and a Meta-analysis was conducted by using Stata17.0 software.Results There were totally 56 articles included.The results of Meta-analysis showed that:①the levels of Hcy,high-density lipoprotein(HDL)and low-density lipoprotein(LDL)were significantly higher in phlegm-damp accumulation group than those in dual deficiency of yin and yang group(P<0.05),and there was no significant difference among hyperactive liver fire group,yin deficiency with yang hyperactivity group and dual deficiency of yin and yang group;②the level of total cholesterol(TC)was significantly higher in phlegm-damp accumulation group,hyperactive liver fire group,and yin deficiency with yang hyperactivity group than that in dual deficiency of yin and yang group;③the level of triglyceride(TG)was significantly higher in phlegm-damp accumulation group and hyperactive liver fire group than that in dual deficiency of yin and yang group,and had no difference compared with yin deficiency with yang hyperactivity group;④The difference in level of hs-CRP(CRP)had no statistical significance among all 4 groups(P>0.05).Conclusion There is a correlation among Hcy,blood lipid level and TCM patterns of EH,and there is no correlation between hs-CRP and TCM patterns of EH.
Keywords：High sensitivity C-reactive proteinHomocysteineBlood lipidEssential hypertensionMeta-analysis
Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 257-262,273 )