Predictive value of uric acid/albumin ratio combined with prognostic nutrition index to contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention
Zhang Xudong
Wang Linsheng
Zhu Yinghua
Qiu Hang
Xu Luhong
Lu Yuan
Li Wenhua
Abstract：Objective To investigate the predictive value of uric acid/albumin ratio(UAR)combined with prognostic nutrition index(PNI)to contrast-induced acute kidney injury(CI-AKI)in patients with ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods STEMI patients undergone PCI(n=1085)were retrospectively chosen into training group from Department of Cardiovascular Medicine in Affiliated Hospital of Xuzhou Medical University from Feb.2019 to May 2023.The elderly STEMI patients undergone PCI(n=370)were chosen into validation group from East Branch of Affiliated Hospital of Xuzhou Medical University from June 2022 to May 2023.The training group was divided,according to CI-AKI occurrence after PCI,into CI-AKI subgroup(n=94)and non-CI-AKI subgroup(n=991).The influence factors for CI-AKI occurrence were analyzed by using single-factor and multi-factor Logistic regression analysis.The predictive value of above factors to CI-AKI was reviewed by using ROC curve.All patients were further grouped according to the results of restricted cubic spline analysis,and the relationship among different groups and CI-AKI risk was compared.Results CI-AKI occurred in 94 patients in this study,and CI-AKI incidence rate was 8.66％.The results of multi-factor Logistic regression analysis showed that age,female,left ventricular ejection fraction(LVEF),diuretics administration,UAR and PNI were independent risk factors for CI-AKI occurrence in STEMI patients after PCI(P＜0.05).The results of ROC curve analysis showed that,in predicting CI-AKI occurrence,AUC of UAR combined with PNI was 0.801(95％CI:0.763～0.839),sensitivity was 83.0％and specificity was 63.8％,which was superior to those of UAR alone or PNI alone.The results of restricted cubic spline analysis showed that UAR＞8.0 was positively correlated to CI-AKI occurrence,and PNI＜37.5 was negatively correlated to CI-AKI occurrence.Conclusion UAR combined with PNI can predict the possibility of CI-AKI occurrence and closely correlated to CI-AKI risk in STEMI patients after PCI.
Keywords：ST-segment elevation myocardial infarctionUric acid/albumin ratioPrognostic nutrition indexContrast-induced acute kidney injuryPercutaneous coronary intervention
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 237-241 )