Correlation among leukocytes and their inflammation-derived indexes and early renal impairment in prehypertension period

Zhou Yiling; Li Hezhi; Ma Jianxin; Wang Guanghui; Cui Lian; Fang Wei; Liu Lili

doi:10.3969/j.issn.1674-4055.2025.02.17

Abstract：Objective To analyze the relationship among early renal impairment,leukocytes and their inflammation-derived indexes in patients with prehypertension(PHT),and provide new diagnostic and therapeutic insights for early renal impairment in PHT patients.Methods PHT patientsf(n=1029)were chosen from Geriatric Ward in Chinese PLA the 305th Hospital from Oct.2022 to Aug.2023.The general clinical materials and laboratory data were collected.The level of serum serum cystatin C(Cys-C)was detected,and value of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio(MLR)and monocyte/high-density lipoprotein-cholesterol ratio(MHR)were calculated.The independent risk factors for PHT early renal impairment were analyzed by using binary multivariate Logistic regression analysis.The diagnostic accuracy of independent or combined indexes was determined after calculating AUC under ROC curve.Results After applying inclusion and exclusion criteria,a total of 1029 PHT patients were chosen,among them there were 75 patients(7.29％)with,and 954(92.71％)without early renal impairment.The results of Pearson correlation analysis showed that white blood cell count(WBC),NLR,MLR and MHR were positively correlated to Cys-C(P＜0.05),and correlation between PLR and Cys-C had no statistical significance(P＞0.05).The results of Logistic regression analysis showed that male,agedness,and increased body mass index(BMI),WBC,NLR,PLR and MLR were risk factors for PHT early renal impairment.The results of ROC curve analysis showed that,in diagnosis with combined gender,age,BMI,WBC,NLR and MLR,AUC was 0.794(95％CI:0.746～0.842),sensitivity was 0.747 and specificity was 0.748.Conclusion The increases of WBC,NLR,PLR and MLR are risk factors for PHT early renal impairment,and combined detection of gender,age,BMI,WBC,NLR and MLR has a higher diagnostic value to PHT early renal impairment.