Predictive value of the fibrinogen-to-albumin ratio for coronary severity in patients with chronic kidney disease
Zhao Mengqi
Zhang Yang
Zhang Songli
Peng Jianjun
Abstract：Objective To investigate the relationship between the fibrinogen-to-albumin ratio(FAR)and the extent of coronary artery disease in patients with chronic kidney disease(CKD).Methods Retrospective analysis was performed on the clinical data of 280 CKD patients who were admitted to the Department of Cardiology,Beijing Shijitan Hospital,Capital Medical University,between January 2021 and January 2023,and underwent their first coronary angiography.According to the tertiles of FAR,patients were divided into three groups:low FAR group,middle FAR group,and high FAR group.The severity and complexity of coronary lesions were assessed using the Gensini scoring system,and the correlation between FAR and the extent of coronary artery disease was analyzed.Results FAR was positively correlated with the Gensini score(r=0.291,P＜0.001).Elevated FAR was an independent risk factor for a high Gensini score(OR=1.161,95％CI:1.070～1.259,P＜0.001).Patients in the high FAR group had higher rates of coronary artery disease,severe coronary artery lesions(three-vessel disease and/or left main disease),chronic total occlusions(P＜0.05),and were more likely to undergo revascularization(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)for FAR in predicting a high Gensini score(＞60)was 0.704(95％CI:0.641～0.767,P＜0.001),with an optimal cutoff value of 8.56％,corresponding to a sensitivity of 73.1％and a specificity of 61.5％.Conclusion In patients with chronic kidney disease,FAR can be used as a non-invasive indicator for predicting the severity of coronary artery disease,and it has clinical value.
Keywords：Coronary atherosclerotic heart diseaseChronic kidney diseaseGensini scoreFibrinogen-to-albumin ratio
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 199-204 )