Risk factors of arrhythmia and evaluation analysis on serum hs-CRP and NT-proBNP in patients with coronary heart disease
Xie Hongmei
Liao Lianmei
Chen Wenxi
Li Jie
Abstract：Objective To analyze the risk factors for arrhythmia occurrence,and discuss the evaluation value of serum high sensitivity C-reactive protein(hs-CRP)and N-terminal pro-brain natriuretic peptide(NT-proBNP)to arrhythmia in patients with coronary heart disease(CHD).Methods CHD patients(n=145)were chosen from People's Hospital of Liangjiang New District in Chongqing from May 2020 to May 2023.All patients were divided,according to arrhythmia occurrence,into non-arrhythmia group(n=61)and arrhythmia group(n=84).The risk factors for arrhythmia occurrence were analyzed in CHD patients,and evaluation value of serum hs-CRP and NT-proBNP to arrhythmia were reviewed by using ROC curve.Results The results of single-factor analysis showed that arrhythmia incidence was higher in patients aged ≥ 60,complicated by smoking history,hypertension and diabetes,with blood potassium level＜3.5 mmol/L,complicated by chronic obstructive pulmonary disease(COPD),with gradeⅢ of angina pectoris classification and without used β-receptor blocker.The results of multi-factor Logistics analysis showed that age,smoking history,complicated by hypertension and diabetes,blood potassium level,complicated by COPD,angina pectoris classification and β-receptor blocker usage were risk factors for arrhythmia occurrence in CHD patients(P＜0.05).The levels of serum hs-CRP and NT-proBNP increased in arrhythmia group compared with non-arrhythmia group(P＜0.05).The results of ROC curve analysis showed that the review value of hs-CRP combined with NT-proBNP was higher than that of single hs-CRP or single NT-proBNP in predicting arrhythmia occurrence.Conclusion Age,smoking history,complicated by hypertension and diabetes,blood potassium level,complicated by COPD,angina pectoris classification and β-receptor blocker usage are risk factors in CHD patients complicated by arrhythmia,and levels of serum hs-CRP and NT-proBNP have a higher predictive value to arrhythmia occurrence in clinical practice.
Keywords：Coronary heart diseaseArrhythmiaHigh sensitivity C-reactive proteinN-terminal pro-brain natriuretic peptide
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 195-198,204 )