Effects of recombinant human brain natriuretic peptide therapy on ventricular remodeling,myocardial injury,and serum inflammatory factors in patients with acute myocardial infarction after PCI
Meng Xianlei
Liu Junfei
Ren Jianming
An Yanxia
Abstract：Objective To investigate the effect of recombinant human brain natriuretic peptide therapy on patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 110 AMI patients who received PCI surgery from July 2020 to May 2023 were selected.According to the postoperative medication regime,55 patients in the control group received routine medication after surgery,and 55 patients in the study group were treated with recombinant human brain natriuretic peptide in addition to the control group's medication regimen.Cardiac function and serum inflammatory factors were compared between the two groups before and after treatment.Major adverse events(MACE)were recorded during the 6-month follow-up after PCI.Results Before treatment,there were no differences in left ventricular diastolic diameter(LVEDD),interventricular septal thickness(IVS),left ventricular end-diastolic diameter(LVD),left ventricular ejection fraction(LVEF),fraction shortening(FS),creatine kinase isoenzyme(CK-MB),troponin T(cTnT),troponin Ⅰ(cTnⅠ),heart fatty acid binding protein(H-FABP),interleukin-6(IL-6),IL-8 and tumor necrosis factor-α between the two groups.After treatment,LVEDD,IVS,LVD,and serum levels of CK-MB,cTnT,cTnⅠ,H-FABP,IL-6,IL-8,and TNF-α decreased significantly in both groups compared to pretreatment levels(P＜0.05),while LVEF and FS increased significantly(P＜0.05).Moreover,post-treatment,these parameters(LVEDD,IVS,LVD,and serum markers)were significantly lower in the study group than in the control group(P＜0.05),while LVEF and FS were significantly higher in the study group(P＜0.05).The incidence of MACEs six months after PCI was significantly lower in the study group than in the control group(18.18％vs.50.91％,P＜0.05).Conclusion Treatment with recombinant human brain natriuretic peptide after PCI in AMI patients can significantly improve myocardial injury,inhibit ventricular remodeling and inflammation,and reduce the incidence of MACEs after PCI.
Keywords：Acute myocardial infarctionRecombinant human brain natriuretic peptidePercutaneous coronary interventionMyocardial injuryVentricular remodelingInflammatory factors
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 185-188 )