Influence of inhibitor of sodium-glucose cotransporter 2 on inflammatory factors in patients with cardi-ovascular risk:a Meta-analysis
Yang Xiaofeng
Wang Linjiang
Chen Ying
Mou Chuan
Yuan Yuan
Wang Haoyu
Abstract：Objective To review systematically the influence of inhibitor of sodium-glucose cotransporter 2(SGLT2)on inflammatory factors in patients with cardiovascular risks.Methods The databases of PubMed,Cochrane Library,EMbase and Web of Science were retrieved with computer taken"sodium glucose transporter 2 inhibitors","inflammation"and"inflammatory biomarkers"as search terms.All randomized controlled trials(RCT)related to influence of SGLT2 on levels of inflammatory factors were searched from database establishment time to Nov.30,2023.All relative literature was screened and included,and given a Meta-analysis by using RevMan5.4 software.Results There were totally 23 RCT included with 2766 patients(including 61.3％of male),and there were 1491 patients in SGLT2 inhibitor group and 1275 in control group.The results of Meta-analysis showed that the levels of high sensitivity C-reactive protein(hs-CRP,SMD:-0.21,95％CI:-0.39～-0.03,P=0.02),tumor necrosis factor-α(TNF-α,[(WMD:0.63,95％CI:-0.95～-0.32,P＜0.0001)],and interleukin-6[(IL-6,WMD:-0.55,95％CI:-0.84～-0.26,P=0.0002)]decreased in SGLT2 inhibitor group compared with control group.The results of subgroup analysis showed that the level of adiponectin increased(SMD=0.17,95％CI:0.02～0.32,P=0.02)in SGLT2 inhibitor group compared with non-pioglitazone control group.The influence of SGLT2 inhibitor group on leptin had no statistical significance(P＞0.05).Conclusion SGLT2 inhibitor can reduce the levels of inflammatory factors including hs-CRP,TNF-α and IL-6,and raise adiponectin level,and its anti-inflammatory effect is expected to relieve cardiovascular events and improve long-term prognosis in patients with cardiovascular risks.
Keywords：Sodium-glucose cotransporter 2Cardiovascular diseasesInflammationMeta-analysisRandomized controlled trial
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 153-160 )