Relationship between sarcopenic obesity and cardiovascular diseases:a systematic review and Me-ta-analysis

Ren Ziyu; Wu Mei; Guo Pengxia; Ao Qi; Yi Shaowei; Li Xingzhi; Zhou Gang; Li Na; Wu Jianjun; Ma Bin

doi:10.3969/j.issn.1674-4055.2025.02.04

Abstract：Objective To review systematically the relationship between sarcopenic obesity(SO)and cardiovascular diseases(CVD)in elderly patients.Methods The databases of PubMed,EMbase,Web of Science,Wanfang Data,CBM,CNKI,and VIP were retrieved for collecting observational studies on the relationship between SO and CVD from database establishment time to Nov.2022.After screened literature,extracted information and evaluated the risk of bias in included studies by 2 investigators independently,and a Meta-analysis was conducted by using STATA15.0 software.The pooled relative odds ratios(ORs)and 95％confidence internals(95％CIs)of CVD risk were calculated in SO patients.Results There were totally 11 studies included with 42683 study subjects.The results of Meta-analysis showed that generally SO was significantly correlated to CVD(OR=2.07,95％CI:1.54～2.77).The results of subgroup analysis further showed that CVD risk increased as age increasing in SO patients.The correlation between SO and coronary artery disease was the most significant.There were differences among different SO criteria in predicting CVD risk,and CVD risk was the highest in SO patients diagnosed by a single test method.Conclusion SO is correlated to increased CVD risk,and age is one of important risk factors for SO affecting CVD.The elderly population should be the current focus of clinical screening.It is necessary to further explore the influence of SO on different CVD events,especially on coronary artery disease.The diagnostic methodology and criteria of SO should be further investigated,in order to promote researches in related fields,and to provide a more precise and effective strategy for preventing and managing cardiovascular risk correlated to SO.