Causal association between frailty and cardiovascular diseases:a two-sample Mendelian randomization analysis
Ren Gaocan
Ding Yanqiu
Yan Zi'an
Ma Xiaochang
Abstract：Objective To review the causal efficacy between frailty and cardiovascular diseases(CVD)by using Mendelian randomization(MS)analysis.Methods The analysis was carried out by using data of genome-wide association study(GWAS).The exposure factor was frailty index,and outcome variables weremyocardial infarction(MI),heart failure(HF),hypertension,atrial fibrillation(AF)and valvular heart disease(VHD).Mendelian randomization(MS)analysis was carried out by using mainly inverse variance-weighted(IVW)and other methods including MR-Egger method,weighted median method and weighted mode method,and horizontal pleiotropy test and heterogeneity test were conducted.Results The results of IVW analysis showed that frailty was related to risk increases of MI(OR=1.926,95％CI:1.687～2.65,P=7.29 × 10-8),HF(OR=1.423,95％CI:1.222～1.624,P=6.01 × 10-4),hypertension(OR=2.173,95％CI:1.910～2.436,P=7.50 × 10-9)and AF(OR=1.791,95％CI:1.415～2.167,P=2.38 × 10-3).There was no evidence to support the association between frailty and VHD(OR=1.138,95％CI:0.917～1.359,P=2.52 × 10-1).There were no horizontal pleiotropy or heterogeneity observed.The results of left one method showed robustness.The results of reverse MR analysis indicated that CVD was positively correlated to frailty risk.Conclusion There is a bidirectional causal association between frailty and CVD,but frailty does not increase VHD risk.
Keywords：FrailtyCardiovascular diseasesMendelian randomizationCausal association
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 129-133 )