Influence of parameters of platelet and morphology and apolipoprotein E polymorphisms on arteriosclerotic cardiovascular disease
Xia Yinglong
Yao Lu
Tian Guoxiang
Liu Jie
Li Na
Chen Yanmei
Wu Yuntao
Abstract：Objective To investigate the influence of platelet count(PLT),platelet morphologic parameters and polymorphismsof apolipoprotein E(APOE)on arteriosclerotic cardiovascular disease(ASCVD).Methods The patients(n=368)undergone coronary computed tomography or coronary angiography(CAG)were chosen from Health Management Center of the Seventh Medical Center ofChinese PLA General Hospital from Aug.2022 to Oct.2023.All patients received laboratory examinations of whole blood cells,blood fat and coagulation factors.The analysis on APOEpolymorphisms was conducted in all patients,and influence of PLT,platelet morphologic parameters and APOEpolymorphisms on ASCVD were analyzed.Results The differences in different genotypes distribution had statistical significance in coronary heart disease(CHD),stroke,peripheralarteriosclerosis,fatty liver and hyperlipidemia.CHD incidence increased significantly in E3 genotype group and E4 genotype group,and stroke incidence increased significantly in E3 genotype group(P＜0.05).The levels of PLT,plateletcrit(PCT),fibrin degradation product(FDP),total cholesterol(TC),low-density lipoprotein-cholesterol(LDL-C),apolipoprotein B(APOB),glycated hemoglobin(HbAlc),apolipoproteina[Lp(a)]and Gensini scores were higher in E4 genotype group than those in E2 genotype group and E3 genotype group(P＜0.05),and levle of fasting plasma glucose(FPG)and arteriosclerosis scores increase significantly in E3 genotype group E4 genotype group(P＜0.05).The results of Logistic regression analysis showed that CHD was correlated to E4allele(OR=10.726),PLT(OR=2.553),PCT(OR=3.637)and arteriosclerosis scores(OR=1.496).Stoke was positively correlated to E3allele(OR=3.245),hypertension(OR=4.966),LDL-C(OR=2.794),PLT(OR=2.273)and mean platelet volume(MPV,OR=1.731).Conclusion APOEpolymorphisms is related to risk of cardiovascular and cerebrovascular diseases.The risk factors of ASCVD related to APOEpolymorphisms are definitely correlated to PLT and platelet morphologic parameters.
Keywords：Coronary heart diseaseAtherosclerosisApolipoprotein EPolymorphismsStroke
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 78-82 )