Factors affecting in-stent restenosis after initial intracoronary implantation of drug-eluting stents
Wang Chunli
Hao Qi
Zhou Qiang
Chen Hongzhen
Abstract：Objective The aim of this study was to investigate the factors affecting in-stent restenosis after initial implantation of drug-eluting stents in coronary arteries.Methods Patients with coronary artery disease treated with DES for the first time in our hospital between January 1,2017 and January 1,2023,who underwent coronary angiography between 6 and 24 months after the procedure,with complete data,were retrospectively included,grouped according to the presence or absence of ISR,and multivariate analyses of the risk factors were performed,using univariate and multivariate binary logistic regression models.Results A total of 559 clinical patients were included in this study,and 81(14.4%)were ISR patients.Univariate analysis showed that gender(χ2=7.883,P=0.005),hypertension(χ2=17.768,P＜0.001),diabetes mellitus(χ2=4.179,P=0.041),hyperuricosuria(χ2=4.416,P=0.036),carotid plaque(χ2=19.698,P＜0.001),mean stent diameter(χ2=6.482,P=0.011),and total stent length(χ2=-12.323,P＜0.001),LDL(Z=-7.224,P＜0.001),fibrinogen(Z=-2.085,P=0.037),and thyroxine(Z=-6.979,P＜0.001)were 10 variables that were influences on ISR,Multifactorial binary logistic regression analysis showed that six variables,namely,sex(OR=0.187,95%CI:0.063～0.555,P=0.003),hypertension(OR=6.253,95%CI:1.777～22.00,P=0.004),diabetes mellitus(OR=3.432,95%CI:1.184～9.950,P=0.023),total length of the stent(OR=1.210,95%CI:1.141～1.282,P＜0.001),low-density lipoprotein(OR=6.697,95%CI:3.085～14.54,P＜0.001),and thyroxine(OR=1.130,95%CI:1.069～1.195,P＜0.001)were 6 variables that were independent influences on ISR.Conclusion Independent influencing factors affecting in-stent restenosis after initial intracoronary implantation of drug-eluting stents are gender,hypertension disease,diabetes mellitus,total stent length,low-density lipoproteins,and thyroxine,which help clinical providers to identify patients at high risk for ISR and optimize therapeutic strategies to improve the prognosis of these patients.
Keywords：Coronary heart diseaseDrug-eluting stentIn-stent restenosisInfluencing factors
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 64-67 )