Neurological complications in patients with patent foramen ovale:a correlation analysis
Ding Fuxia
Sun Shougang
Abstract：Objective To investigate the relationship among morphology,pore diameter,grades of right-to-left shunt(RLS)and types of patent foramen ovale(PFO)and neurological complications in PFO patients.Methods The clinical materials from PFO patients(n=279)were retrospectively analyzed,and they were divided into groupwith complications(n=181)and group without complications(n=98)according to they had or not neurological complicationsincluding migraine,stroke and unexplained syncope.The image materials of transthoracic echocardiography(TTE),transesophageal echocardiography(TEE)and contrast-enhanced transcranial Doppler(cTCD),and clinical data were collected.The relationship among morphology,pore diameter,grades of RLS and types of PFO and neurological complications based on results of TTE/TEE and cTCD.Results The comparisons in age,gender and PFO pore diameter had no significant differences between 2 groups(P＞0.05).The percentages of complex PFO,high RLS grade and inherent RLS were higher in group without complications than those in groupwith complications(P＜0.05).The results of multi-factor Logistic regression analysis showed that complex PFO(OR=3.843,95%CI:2.176～6.787,P＜0.001),high RLS grade(OR=2.482,95%CI:1.499～4.109,P＜0.001)and inherentRLS(OR=7.424,95%CI:3.369～16.361,P＜0.001)were independent risk factors for neurological complications,and PFO pore diameter was not correlated to neurological complications.Conclusion Complex PFO,high RLS grade and inherent RLS are independent risk factors for neurological complications,and PFO pore diameter is not correlated to neurological complications.
Keywords：Foramen oval morphologyForamen oval pore diameterRight-to-left shuntPatent foramen ovaleNeurological complications
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 59-63,67 )