Correlation among serum polyadenosine diphosphate ribose polymerase 1,apolipoprotein M and myocardial remodeling in patients with coronary heart disease
Zhou Kuo
Zhou Yutian
Zhan Yiyang
Abstract：Objective To discuss the correlation among polyadenosine diphosphate ribose polymerase 1 (PARP1),apolipoprotein M (apoM) and myocardial remodeling in patients with coronary atherosclerosis heart disease (CHD).Methods CHD patients (n=125) were chosen into case group and healthy controls were chosen into control group (n=120) from People's Hospital of Jiangsu Province from June 2023 to June 2024.The changes of PARP1,apoM,left ventricular end-diastolic diameter (LVEDd)left ventricular end-diastolic diameter (LVEDD),left atrial diameter (LAD),left ventricular posterior wall thickness (LVPW),left ventricular mass index (LVMI) and left ventricular remodeling index (LVRI) and relationship between them and myocardial remodeling were compared and analyzed in 2 groups.Results The level of PARP1 was higher,and apoM level was lower in case group than those in control group (P＜0.05).The levels of LVEDD,LAD,LVPW and LVMI were higher,and LVRI level was lower in case group than those in control group (P＜0.05).The levels of PARP1,LVEDD,LAD,LVPW and LVMIwere lower,and levels of apoM and LVRI were higher in patients with stable angina pectoris (SAP) than those in patients with unstable angina pectoris (UAP) and myocardial infarction (MI),and levels of PARP1,LVEDD,LAD,LVPW and LVMI were lower,and levels of apoM and LVRI were higher in UAP patients than those in MI patients (P＜0.05).The results of correlation analysis showed that PARP1 was positively correlated to LVEDD,LAD,LVPW and LVMI and negatively correlated to LVRI,and apoM was negatively correlated to LVEDD,LAD,LVPW and LVMI and positively correlated to LVRI in CHD patients (P＜0.05).Conclusion The level of PARP1 increases and apoM level decreases,and they are correlated to myocardial remodeling in CHD patients,which is expected to open up a new ideas for CHD prevention and treatment.
Keywords：Coronary atherosclerosis heart diseasePolyadenosine diphosphate ribose polymerase 1Apolipoprotein MMyocardial remodeling
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1531-1533,1537 )